Salvia Divinorum or Diverner’s sage is considered the best herb among the thousands of Salvia species. It is an extraordinary herb used for healing, medication and divination by Mazatec Indians. Due to limited research conducted on Salvia Divinorum, the information about chemistry of Salvia Divinorum is also quiet restrained. But as the herb has gained popularity in last couple of years, this has pursued scientists also to take keen interest in the chemistry of Salvia Divinorum. Due to the presence of Salvinorin in the herb, Salvia Divinorum is marked as the best Salvia herb and hence makes it superior to other types of sages. Salvinorin constitutes majorly of Salvinorin A and Salvinorin B and the group of its compounds is known as neoclerodane diterpenoids. Out of the two constituents, Salvinorin A is the primary component and the formula for same is C23H28O8. This component is also referred as psychoactive compound. Unlike most other natural drugs, Salvinorin A doesn’t contain a basic nitrogen atom and hence the component is not an alkaloid. The chemistry of Salvia Divinorum is in such a manner that its component does give a negative reaction on urine tests. This unique quality makes it incomparable with any other drug. Salvinorin A is the only proved Divinorum contained in the herb which produces psychoactive effects But according to many researchers, Salvia Divinorum may also contain other psychoactive substance namely, Divinorum C. The chemistry of Salvia Divinorum is still a mystery, but soon researchers would be able to provide us with complete details on the subject.